Actin Regulation of the Morphology, Dynamics, and Development of Dendritic Filopodia
AuthorLy, Kenneth Tran
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PublisherThe University of Arizona.
RightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction, presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
AbstractDendritic filopodia (DF) are thin, highly dynamic structures that project from neuronal dendrites. Once a DF finds and latches onto an axon from another neuron, the DF develops into the postsynaptic portion of a mature synapse. Synapses and their development from DF form the foundation of learning and memory and are implicated in many neurological diseases. The dynamics, morphology, and development of DF are heavily dependent on the actin reorganization within them. Because DF are composed of branched actin filaments, DF are distinct from conventional filopodia, which are composed of parallel, straight actin filaments. Thus, the actin regulation of DF is unique. This thesis will consider some of the proteins reported in the literature to be involved in actin regulation in DF, such as profilin, formins, the enabled (Ena)/vasodilator-stimulated phosphoprotein (VASP) homology proteins, the actin-related protein 2/3 (Arp2/3) complex, metastasis suppressor 1 (MTSS1)/missing-in-metastasis (MIM), and actin-depolymerizing factor (ADF)/cofilin, and synthesize the information to propose a comprehensive model of DF development. A deeper understanding of the regulation of DF can open the door for future research into the mechanisms of many diseases and new interventions and therapeutics for them.
Degree ProgramGraduate College
Molecular & Cellular Biology