Kastner, Joel H.; Principe, David A.; Punzi, Kristina; Stelzer, Beate; Gorti, Uma; Pascucci, Ilaria; Argiroffi, Costanza; Univ Arizona, Lunar & Planetary Lab (IOP PUBLISHING LTD, 2016-06-13)
      To investigate the potential connection between the intense X-ray emission from young low-mass stars and the lifetimes of their circumstellar planet-forming disks, we have compiled the X-ray luminosities (L-X) of M stars in the similar to 8 Myr old TW Hya Association (TWA) for which X-ray data are presently available. Our investigation includes analysis of archival Chandra data for the TWA binary systems TWA 8, 9, and 13. Although our study suffers from poor statistics for stars later than M3, we find a trend of decreasing L-X/L-bol with decreasing T-eff for TWA M stars, wherein the earliest-type (M0-M2) stars cluster near log(L-X/L-bol) approximate to -3.0 and then log(L-X/L-bol) decreases, and its distribution broadens, for types M4 and later. The fraction of TWA stars that display evidence for residual primordial disk material also sharply increases in this same (mid-M) spectral type regime. This apparent anticorrelation between the relative X-ray luminosities of low-mass TWA stars and the longevities of their circumstellar disks suggests that primordial disks orbiting early-type M stars in the TWA have dispersed rapidly as a consequence of their persistent large X-ray fluxes. Conversely, the disks orbiting the very lowest-mass pre-MS stars and pre-MS brown dwarfs in the Association may have survived because their X-ray luminosities and, hence, disk photoevaporation rates are very low to begin with, and then further decline relatively early in their pre-MS evolution.
    • The M101 Satellite Luminosity Function and the Halo–Halo Scatter among Local Volume Hosts

      Bennet, P.; Sand, D. J.; Crnojević, D.; Spekkens, K.; Karunakaran, A.; Zaritsky, D.; Mutlu-Pakdil, B.; Univ Arizona, Steward Observ (IOP PUBLISHING LTD, 2019-11-11)
      We have obtained deep Hubble Space Telescope (HST) imaging of 19 dwarf galaxy candidates in the vicinity of M101. Advanced Camera for Surveys HST photometry for two of these objects showed resolved stellar populations and tip of the red giant branch derived distances (D & xfffd;?& xfffd;7 Mpc) consistent with M101 group membership. The remaining 17 were found to have no resolved stellar populations, meaning they are either part of the background NGC 5485 group or are distant low surface brightness (LSB) galaxies. It is noteworthy that many LSB objects that had previously been assumed to be M101 group members based on projection have been shown to be background objects, indicating the need for future diffuse dwarf surveys to be very careful in drawing conclusions about group membership without robust distance estimates. In this work we update the satellite luminosity function of M101 based on the presence of these new objects down to M-V & xfffd;=& xfffd;?8.2. M101 is a sparsely populated system with only nine satellites down to M-V ?8, as compared with 26 for M31 and 24.5 & xfffd;& xfffd;7.7 for the median host in the Local Volume. This makes M101 by far the sparsest group probed to this depth, although M94 is even sparser to the depth at which it has been examined (M-V & xfffd;=& xfffd;?9.1). M101 and M94 share several properties that mark them as unusual compared with the other Local Volume galaxies examined: they have a very sparse satellite population but also have high star-forming fractions among these satellites; such properties are also found in the galaxies examined as part of the Satellites around Galactic Analogs survey. We suggest that these properties appear to be tied to the wider galactic environment, with more isolated galaxies showing sparse satellite populations that are more likely to have had recent star formation, while those in dense environments have more satellites that tend to have no ongoing star formation. Overall, our results show a level of halo-to-halo scatter between galaxies of similar mass that is larger than is predicted in the lambda cold dark matter model.
    • Machine learning can accurately predict pre-admission baseline hemoglobin and creatinine in intensive care patients

      Dauvin, Antonin; Donado, Carolina; Bachtiger, Patrik; Huang, Ke-Chun; Sauer, Christopher Martin; Ramazzotti, Daniele; Bonvini, Matteo; Celi, Leo Anthony; Douglas, Molly J; Univ Arizona, Coll Med (NATURE PUBLISHING GROUP, 2019-11-29)
      Patients admitted to the intensive care unit frequently have anemia and impaired renal function, but often lack historical blood results to contextualize the acuteness of these findings. Using data available within two hours of ICU admission, we developed machine learning models that accurately (AUC 0.86–0.89) classify an individual patient’s baseline hemoglobin and creatinine levels. Compared to assuming the baseline to be the same as the admission lab value, machine learning performed significantly better at classifying acute kidney injury regardless of initial creatinine value, and significantly better at predicting baseline hemoglobin value in patients with admission hemoglobin of <10 g/dl.
    • Machine-learning-based Brokers for Real-time Classification of the LSST Alert Stream

      Narayan, Gautham; Zaidi, Tayeb; Soraisam, Monika D.; Wang, Zhe; Lochner, Michelle; Matheson, Thomas; Saha, Abhijit; Yang, Shuo; Zhao, Zhenge; Kececioglu, John; et al. (IOP PUBLISHING LTD, 2018-05)
      The unprecedented volume and rate of transient events that will be discovered by the Large Synoptic Survey Telescope (LSST) demand that the astronomical community update its follow-up paradigm. Alert-brokers-automated software system to sift through, characterize, annotate, and prioritize events for follow-up-will be critical tools for managing alert streams in the LSST era. The Arizona-NOAO Temporal Analysis and Response to Events System (ANTARES) is one such broker. In this work, we develop a machine learning pipeline to characterize and classify variable and transient sources only using the available multiband optical photometry. We describe three illustrative stages of the pipeline, serving the three goals of early, intermediate, and retrospective classification of alerts. The first takes the form of variable versus transient categorization, the second a multiclass typing of the combined variable and transient data set, and the third a purity-driven subtyping of a transient class. Although several similar algorithms have proven themselves in simulations, we validate their performance on real observations for the first time. We quantitatively evaluate our pipeline on sparse, unevenly sampled, heteroskedastic data from various existing observational campaigns, and demonstrate very competitive classification performance. We describe our progress toward adapting the pipeline developed in this work into a real-time broker working on live alert streams from time-domain surveys.
    • Macroeconomic dynamics and the IS puzzle

      Hawkins, Raymond J.; Nguyen, Chau N.; Univ Arizona, Coll Opt Sci (KIEL INST WORLD ECONOMY, 2018-09-18)
      The authors solve the IS puzzle for the G7 countries. They find that five of the G7 countries have the expected significant negative relationship between the output gap and the realrate gap; the time series of the remaining two show material deviation from expected IS-curve behavior. The authors show that the observed time dependence of the interaction between the output and real-rate gaps can be represented in a parsimonious and practical manner using the theory of anelasticity that unifies partial-adjustment specifications of the IS curve.
    • Macrophage migration inhibitory factor: controller of systemic inflammation

      Larson, Douglas; Horak, Katherine; Sarver Heart Center and Departments of Surgery and Medical Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, USA (BioMed Central, 2006)
      Macrophage migration inhibitory factor (MIF) is a cytokine that is secreted by the anterior pituitary and immune cells in response to surgical stress, injury, and sepsis. This cytokine appears to be a critical regulator of the inflammatory pathways, leading to systemic inflammatory response syndrome and subsequent multiple organ dysfunction syndrome. This report provides an integrated scheme describing the manner by which MIF controls the neurohormonal response and the adaptive immune system, namely the T-helper (Th)1 and Th2 lymphocytes, which results in the release of pro-inflammatory cytokines and the anti-inflammatory cytokine interleukin-10. The development of systemic inflammatory response syndrome and subsequent development of multiple organ dysfunction syndrome appear to be related to MIF levels and the balance of Th1 and Th2 function.

      Rodigas, Timothy J.; Bergeron, P.; Simon, Amélie; Arriagada, Pamela; Faherty, Jacqueline K.; Anglada-Escudé, Guillem; Mamajek, Eric E.; Weinberger, A. J.; Butler, R. Paul; Males, Jared R.; et al. (IOP PUBLISHING LTD, 2016-11-04)
      HD 11112 is an old, Sun-like star that has a long-term radial velocity (RV) trend indicative of a massive companion on a wide orbit. Here we present direct images of the source responsible for the trend using the Magellan Adaptive Optics system. We detect the object (HD 11112B) at a separation of 2 2 (100 au) at multiple wavelengths spanning 0.6-4 mu m. and show that it is most likely a gravitationally bound cool white dwarf. Modeling its spectral energy distribution suggests that its mass is 0.9-1.1M(circle dot), which corresponds to very high eccentricity, near edge-on orbits from a. Markov chain Monte Carlo analysis of the RV and imaging data together. The total age of the white dwarf is > 2 sigma, which is discrepant with that of the primary star under most assumptions. The problem can be resolved if the white dwarf progenitor was initially a double white dwarf binary that then merged into the observed high-mass white dwarf. HD 11112B is a unique and intriguing benchmark object that can be used to calibrate atmospheric and evolutionary models of cool white dwarfs and should thus continue to be monitored by RV and direct imaging over the coming years.
    • MagAO: status and science

      Morzinski, Katie M.; Close, Laird M.; Males, Jared R.; Hinz, Phil M.; Esposito, Simone; Riccardi, Armando; Briguglio, Runa; Follette, Katherine B.; Pinna, Enrico; Puglisi, Alfio; et al. (SPIE-INT SOC OPTICAL ENGINEERING, 2016-07-26)
      MagAO is the adaptive optics instrument at the Magellan Clay telescope at Las Campanas Observatory, Chile. MagAO has a 585-actuator adaptive secondary mirror and 1000-Hz pyramid wavefront sensor, operating on natural guide stars from R-magnitudes of -1 to 15. MagAO has been in on-sky operation for 166 nights since installation in 2012. MagAO's unique capabilities are simultaneous imaging in the visible and infrared with VisAO and Clio, excellent performance at an excellent site, and a lean operations model. Science results from MagAO include the first ground-based CCD image of an exoplanet, demonstration of the first accreting protoplanets, discovery of a new wide-orbit exoplanet, and the first empirical bolometric luminosity of an exoplanet. We describe the status, report the AO performance, and summarize the science results. New developments reported here include color corrections on red guide stars for the wavefront sensor; a new field stop stage to facilitate VisAO imaging of extended sources; and eyepiece observing at the visible-light diffraction limit of a 6.5-m telescope. We also discuss a recent hose failure that led to a glycol coolant leak, and the recovery of the adaptive secondary mirror (ASM) after this recent (Feb. 2016) incident.
    • Magellan Adaptive Optics Imaging of PDS 70: Measuring the Mass Accretion Rate of a Young Giant Planet within a Gapped Disk

      Wagner, Kevin; Follete, Katherine B.; Close, Laird M.; Apai, Dániel; Gibbs, Aidan; Keppler, Miriam; Müller, André; Henning, Thomas; Kasper, Markus; Wu, Ya-Lin; et al. (IOP PUBLISHING LTD, 2018-08-10)
      PDS 70b is a recently discovered and directly imaged exoplanet within the wide (greater than or similar to 40 au) cavity around PDS 70. Ongoing accretion onto the central star suggests that accretion onto PDS 70b may also be ongoing. We present the first high-contrast images at H alpha (656 nm) and nearby continuum (643 nm) of PDS 70 utilizing the MagAO system. The combination of these filters allows for the accretion rate of the young planet to be inferred, as hot infalling hydrogen gas will emit strongly at H alpha over the optical continuum. We detected a source in H alpha at the position of PDS 70b on two sequential nights in 2018 May, for which we establish a false positive probability of <0.1%. We conclude that PDS 70b is a young, actively accreting planet. We utilize the H alpha line luminosity to derive a mass accretion rate of (M) over dot = 10(-8 +/- 1) M-Jup yr(-1), where the large uncertainty is primarily due to the unknown amount of optical extinction from the circumstellar and circumplanetary disks. PDS 70b represents the second case of an accreting planet interior to a disk gap, and is among the early examples of a planet observed during its formation.

      Wu, Ya-Lin; Close, Laird M.; Bailey, Vanessa P.; Rodigas, Timothy J.; Males, Jared R.; Morzinski, Katie M.; Follette, Katherine B.; Hinz, Philip M.; Puglisi, Alfio; Briguglio, Runa; et al. (IOP PUBLISHING LTD, 2016-05-17)
      We analyze archival data from Bailey and co-workers from the Magellan adaptive optics system and present the first 0.9 mu m detection (z' = 20.3 +/- 0.4 mag; Delta z' = 13.0 +/- 0.4 mag) of the 11 M-Jup circumbinary planet HD 106906AB b, as well as 1 and 3.8 mu m detections of the debris disk around the binary. The disk has an east-west asymmetry in length and surface brightness, especially at 3.8 mu m where the disk appears to be one-sided. The spectral energy distribution of b, when scaled to the K-S-band photometry, is consistent with 1800 K atmospheric models without significant dust reddening, unlike some young, very red, low-mass companions such as CT Cha B and 1RXS 1609 B. Therefore, the suggested circumplanetary disk of Kalas and co-workers might not contain much material, or might be closer to face-on. Finally, we suggest that the widest (a greater than or similar to 100 AU) low mass ratio (M-p/M-star = q less than or similar to 0.01) companions may have formed inside protoplanetary disks but were later scattered by binary/planet interactions. Such a scattering event may have occurred for HD 106906AB b with its central binary star, but definitive proof at this time is elusive.
    • A Magellan M2FS Spectroscopic Survey of Galaxies at 5.5 < z < 6.8: Program Overview and a Sample of the Brightest Lyα Emitters

      Jiang, Linhua; Shen, Yue; Bian, Fuyan; Zheng, Zhen-Ya; Wu, Jin; Oyarzún, Grecco A.; Blanc, Guillermo A.; Fan, Xiaohui; Ho, Luis C.; Infante, Leopoldo; et al. (IOP PUBLISHING LTD, 2017-09-11)
      We present a spectroscopic survey of high-redshift, luminous galaxies over four square degrees on the sky, aiming to build a large and homogeneous sample of Ly alpha emitters (LAEs) at z approximate to 5.7 and 6.5, and Lyman-break galaxies (LBGs) at 5.5 < z < 6.8. The fields that we choose to observe are well studied, such as by the Subaru XMM-Newton Deep Survey and COSMOS. They have deep optical imaging data in a series of broad and narrow bands, allowing for the efficient selection of galaxy candidates. Spectroscopic observations are being carried out using the multi-object spectrograph M2FS on the Magellan Clay telescope. M2FS is efficient enough to identify high-redshift galaxies, owing to its 256 optical fibers deployed over a circular field of view 30' in diameter. We have observed similar to 2.5 square degrees. When the program is completed, we expect to identify more than 400 bright LAEs at z approximate to 5.7 and 6.5, and a substantial number of LBGs at z >= 6. This unique sample will be used to study a variety of galaxy properties and to search for large protoclusters. Furthermore, the statistical properties of these galaxies will be used to probe cosmic reionization. We describe the motivation, program design, target selection, and M2FS observations. We also outline our science goals, and present a sample of the brightest LAEs at z approximate to 5.7 and 6.5. This sample contains 32 LAEs with Ly alpha luminosities higher than 10(43) erg s(-1). A few of them reach >= 3 x 10(43) erg s(-1), comparable to the two most luminous LAEs known at z >= 6, "CR7" and "COLA1." These LAEs provide ideal targets to study extreme galaxies in the distant universe.
    • Magellan/M2FS Spectroscopy of Galaxy Clusters: Stellar Population Model and Application to Abell 267

      Tucker, Evan; Walker, Matthew G.; Mateo, Mario; Olszewski, Edward W.; Bailey, John I.; Crane, J. D.; Shectman, Stephen A.; Univ Arizona, Steward Observ (IOP PUBLISHING LTD, 2017-08-29)
      We report the results of a pilot program to use the Magellan/M2FS spectrograph to survey the galactic populations and internal kinematics of galaxy clusters. For this initial study, we present spectroscopic measurements for 223 quiescent galaxies observed along the line of sight of the galaxy cluster Abell 267 (z similar to 0.23). We develop a Bayesian method for modeling the integrated light from each galaxy as a simple stellar population, with free parameters that specify the redshift (v(los)/c) and characteristic age, metallicity ([Fe/H]), alpha-abundance ([alpha/Fe]), and internal velocity dispersion (sigma(int)) for individual galaxies. Parameter estimates derived from our 1.5 hr observation of A267 have median random errors of sigma(vlos) = 20 km s(-1), sigma(Age) = 1.2 Gyr, sigma([Fe/H]) = 0.11 dex, sigma([alpha/Fe]) = 0.07 dex, and sigma(sigma int) = 20 km s(-1). In a companion paper, we use these results to model the structure and internal kinematics of A267.
    • Magma Recharge and Reactive Bulk Assimilation in Enclave-Bearing Granitoids, Tonglu, South China

      Yu, Kaizhang; Liu, Yongsheng; Hu, Qinghai; Ducea, Mihai N; Hu, Zhaochu; Zong, Keqing; Chen, Haihong; Univ Arizona, Dept Geosci (OXFORD UNIV PRESS, 2018-05)
      Magmatic processes leading to granitoid formation are of relevance to the evolution of continental crust and its mineralization. A comprehensive study of field observations with whole-rock and in situ mineral chemical and isotopic compositions was carried out on granitoids, mafic microgranular enclaves (MME) and country-rock xenoliths (CRX) from Tonglu, South China to constrain the magmatic processes operating. Zircon U-Pb geochronology indicates that the MME and granitoids formed coevally at similar to 130 Ma. Petrographic observations suggest that the MME are quenched mafic clots formed during incomplete magma mixing. The different zircon Hf isotopic compositions of the MME (eHf(t) 1/4 -4.0 to -0.7) and the host granitoids (epsilon(Hf)(t) = -8.1 to -1.7) indicate mingling between mafic and felsic magmas from different sources. The CRX are composed of fresh cores and dark rims. The pyroxene-rich fresh cores are depleted in Rb, Ba and K while the biotite-rich dark rims show obvious enrichments in Rb, Ba and K, indicating modification by hydrous K-rich felsic melts or fluids from the host magma. In contrast, some large CRX have embayed structures and are surrounded by several small, biotite-rich CRX, suggesting disaggregation and modification of large CRX into the host magma. The occurrence of abundant felsic magmatic veinlets in the CRX implies that they could have experienced brittle deformation in the cold shallow crust, which agrees with an emplacement depth of about 5 km estimated using Al-in hornblende geobarometry. The high Sr-87/(86)Sri (0.7129) and low eNd(t) (-10.2) values imply that these CRX were derived from the upper continental crust. All these features suggest a typical reactive bulk assimilation process. Microanalysis of Sr-87/Sr-86 ratios in plagioclase from the Tonglu granitoids vary over a large range (0.7073-0.7137) with complex rim-core-rim variations, which resulted from open-system processes. Given the variation in Sr isotopes, four types of plagioclase were identified. Type I plagioclase are homogeneous in terms of Sr-87/Sr-86, suggesting normal crystal fractionation. Recharge of mafic magma injecting into felsic magma resulted in the core-mantle variations of type II plagioclases. Albitic cores with high Sr-87/Sr-86 (up to 0.7092) indicate felsic magma with highly radiogenic Sr (Sr-87/Sr-86> 0.7092). Influx of mafic magma with less radiogenic Sr (Sr-87/Sr-86<0.7080) resulted in a decrease in Sr-87/Sr-86 and an abrupt increase of An contents (similar to An(30) to similar to An(60)) from core to mantle. Type III plagioclase are distinguished by lower Sr-87/Sr-86 ratios in the core (0.7084-0.7086) and significantly more radiogenic Sr at the rim (0.7097-0.7112), which is attributed to the assimilation of the country rocks. Core-mantle-rim variations in type IV plagioclase not only record magma recharge events, but also crustal assimilation. Increasing An values and decreasing Sr-87/Sr-86 ratios (down to 0.7075) from core to mantle and significantly more radiogenic Sr (up to 0.7117) in the outer rim suggest that the recharge event took place prior to the assimilation of ancient crustal
    • Magmatic evolution of a Cordilleran flare-up and its role in the creation of silicic crust

      Ward, Kevin M.; Delph, Jonathan R.; Zandt, George; Beck, Susan L.; Ducea, Mihai N.; Univ Arizona, Dept Geosci (NATURE PUBLISHING GROUP, 2017-08-22)
      The role of magmatic processes as a significant mechanism for the generation of voluminous silicic crust and the development of Cordilleran plateaus remains a lingering question in part because of the inherent difficulty in quantifying plutonic volumes. Despite this difficulty, a growing body of independently measured plutonic-to-volcanic ratios suggests the volume of plutonic material in the crust related to Cordilleran magmatic systems is much larger than is previously expected. To better examine the role of crustal magmatic processes and its relationship to erupted material in Cordilleran systems, we present a continuous high-resolution crustal seismic velocity model for an similar to 800 km section of the active South American Cordillera (Puna Plateau). Although the plutonic-to-volcanic ratios we estimate vary along the length of the Puna Plateau, all ratios are larger than those previously reported (similar to 30: 1 compared to 5: 1) implying that a significant volume of intermediate to silicic plutonic material is generated in the crust of the central South American Cordillera. Furthermore, as Cordilleran-type margins have been common since the onset of modern plate tectonics, our findings suggest that similar processes may have played a significant role in generating and/or modifying large volumes of continental crust, as observed in the continents today.
    • Magnetic anomalies concentrated near and within Mercury's impact basins: Early mapping and interpretation

      Hood, L. L.; Univ Arizona, Lunar & Planetary Lab; Lunar and Planetary Laboratory; University of Arizona; Tucson Arizona USA (AMER GEOPHYSICAL UNION, 2016-06)
    • Magnetic anomalies in the Imbrium and Schrödinger impact basins: Orbital evidence for persistence of the lunar core dynamo into the Imbrian epoch

      Hood, Lon L.; Spudis, P. D.; Univ Arizona, Lunar & Planetary Lab; Lunar and Planetary Laboratory; University of Arizona; Tucson Arizona USA; Lunar and Planetary Institute; Houston Texas USA (AMER GEOPHYSICAL UNION, 2016-11)
      Approximate maps of the lunar crustal magnetic field at low altitudes in the vicinities of the three Imbrian-aged impact basins, Orientale, Schrdinger, and Imbrium, have been constructed using Lunar Prospector and Kaguya orbital magnetometer data. Detectable anomalies are confirmed to be present well within the rims of Imbrium and Schrdinger. Anomalies in Schrdinger are asymmetrically distributed about the basin center, while a single isolated anomaly is most clearly detected within Imbrium northwest of Timocharis crater. The subsurface within these basins was heated to high temperatures at the time of impact and required long time periods (up to 1 Myr) to cool below the Curie temperature for metallic iron remanence carriers (1043 K). Therefore, consistent with laboratory analyses of returned samples, a steady, long-lived magnetizing field, i.e., a former core dynamo, is inferred to have existed when these basins formed. The asymmetrical distribution within Schrdinger suggests partial demagnetization by later volcanic activity when the dynamo field was much weaker or nonexistent. However, it remains true that anomalies within Imbrian-aged basins are much weaker than those within most Nectarian-aged basins. The virtual absence of anomalies within Orientale where impact melt rocks (the Maunder Formation) are exposed at the surface is difficult to explain unless the dynamo field was much weaker during the Imbrian period.
    • Magnetic Reconnection May Control the Ion-scale Spectral Break of Solar Wind Turbulence

      Vech, Daniel; Mallet, Alfred; Klein, Kristopher G.; Kasper, Justin C.; Univ Arizona, Lunar & Planetary Lab (IOP Publishing, 2018-03-15)
      The power spectral density of magnetic fluctuations in the solar wind exhibits several power-law-like frequency ranges with a well-defined break between approximately 0.1 and 1 Hz in the spacecraft frame. The exact dependence of this break scale on solar wind parameters has been extensively studied but is not yet fully understood. Recent studies have suggested that reconnection may induce a break in the spectrum at a “disruption scale” lD, which may be larger than the fundamental ion kinetic scales, producing an unusually steep spectrum just below the break. We present a statistical investigation of the dependence of the break scale on the proton gyroradius ρi, ion inertial length di, ion sound radius ρs, proton–cyclotron resonance scale ρc, and disruption scale lD as a function of b^i. We find that the steepest spectral indices of the dissipation range occur when βe is in the range of 0.1–1 and the break scale is only slightly larger than the ion sound scale (a situation occurring 41% of the time at 1 au), in qualitative agreement with the reconnection model. In this range, the break scale shows a remarkably good correlation with lD. Our findings suggest that, at least at low βe, reconnection may play an important role in the development of the dissipation range turbulent cascade and cause unusually steep (steeper than −3) spectral indices.
    • Magnetic resonance imaging of RRx-001 pharmacodynamics in preclinical tumors

      Raghunand, Natarajan; Scicinski, Jan; Guntle, Gerald P.; Jagadish, Bhumasamudram; Mash, Eugene A.; Bruckheimer, Elizabeth; Oronsky, Bryan; Korn, Ronald L.; Univ Arizona, Arizona Canc Ctr; Univ Arizona, Dept Chem & Biochem (IMPACT JOURNALS LLC, 2017-06-13)
      RRx-001 is an anticancer agent that subjects cancer cells to reactive oxygen/nitrogen species (ROS/RNS) and acts as an epigenetic modifier. We have used a thiol-bearing MRI contrast agent, Gd-LC7-SH, to investigate the pharmacodynamics of RRx-001 in CHP-100 Ewing's Sarcoma, HT-29 colorectal carcinoma, and PANC-1 pancreatic carcinoma xenografts in SCID mice. Binding of Gd-LC7-SH to the Cys34 residue on plasma albumin prolongs retention in the tumor microenvironment and increases tumor enhancement on MRI. Mice were imaged by MRI and in vivo T1 maps acquired 50 min (T1(50 min)) after injection of 0.05 mmol/kg Gd-LC7-SH (i.v.) at baseline and 1, 24, and 72 h post-treatment with 10 mg/kg RRx-001 (i.v.). Consistent with an indirect thiol-modifying activity of RRx-001, tumor T150 min at 1 h post-drug was significantly longer than pre-drug tumor T150 min in all three tumor models, with the T150 min remaining significantly longer than baseline through 72 h post-drug in the HT-29 and PANC-1 tumors. The T150 min of CHP-100 tumors recovered to baseline by 24 h post-drug, suggesting a robust anti-oxidant response to the RRx-001 challenge that was presaged by a marked increase in perfusion at 1 h post-drug measured by DCE-MRI. MRI enhanced with Gd-LC7-SH provides a mechanistically rational biomarker of RRx-001 pharmacodynamics.
    • Magnetic reversal and thermal stability of CoFeB perpendicular magnetic tunnel junction arrays patterned by block copolymer lithography

      Tu, Kun-Hua; Fernandez, Eduardo; Almasi, Hamid; Wang, Weigang; Otero, David Navas; Ntetsikas, Konstantinos; Moschovas, Dimitrios; Avgeropoulos, Apostolos; Ross, Caroline A; Univ Arizona, Dept Phys (IOP PUBLISHING LTD, 2018)
      Dense arrays of pillars, with diameters of 64 and 25 nm, were made from a perpendicular CoFeB magnetic tunnel junction thin film stack using block copolymer lithography. While the soft layer and hard layer in the 64 nm pillars reverse at different fields, the reversal of the two layers in the 25 nm pillars could not be distinguished, attributed to the strong interlayer magnetostatic coupling. First-order reversal curves were used to identify the steps that occur during switching, and the thermal stability and effective switching volume were determined from scan rate dependent hysteresis measurements.
    • Magnetization switching using topological surface states

      Li, Peng; Kally, James; Zhang, Steven S-L; Pillsbury, Timothy; Ding, Jinjun; Csaba, Gyorgy; Ding, Junjia; Jiang, J S; Liu, Yunzhi; Sinclair, Robert; et al. (AMER ASSOC ADVANCEMENT SCIENCE, 2019-08-30)
      Topological surface states (TSSs) in a topological insulator are expected to be able to produce a spin-orbit torque that can switch a neighboring ferromagnet. This effect may be absent if the ferromagnet is conductive because it can completely suppress the TSSs, but it should be present if the ferromagnet is insulating. This study reports TSS-induced switching in a bilayer consisting of a topological insulator Bi2Se3 and an insulating ferromagnet BaFe12O19. A charge current in Bi2Se3 can switch the magnetization in BaFe12O19 up and down. When the magnetization is switched by a field, a current in Bi2Se3 can reduce the switching field by ~4000 Oe. The switching efficiency at 3 K is 300 times higher than at room temperature; it is ~30 times higher than in Pt/BaFe12O19. These strong effects originate from the presence of more pronounced TSSs at low temperatures due to enhanced surface conductivity and reduced bulk conductivity.