ABOUT THE COLLECTIONS

More than 40,000 theses and dissertations produced at the University of Arizona are included in the UA Theses and Dissertations collections. These items are publicly available and full-text searchable. A small percentage of items are under embargo (restricted).

We have digitized the entire backfile of UA master's theses and doctoral dissertations that were held in the University of Arizona Libraries.

  • Submitting master's theses to the UA Libraries was optional for many decades; as a result, we do not have all master's theses that were written at the University of Arizona.
  • A small number of historical theses containing culturally sensitive material are not available online.
If you can't find the item you want in the repository and would like to check with us, please contact the Campus Repository team at repository@u.library.arizona.edu.


You can also refer to the Theses & Dissertations - frequently asked questions guide to find materials that are not available online.

Collections in this community

Recent Submissions

  • EFFECTS OF DEVICE-GUIDED BREATHING TRAINING AFTER MYOCARDIAL REVASCULARIZATION

    Bailey, Fiona; Soria, Sebastian (The University of Arizona., 2023)
    Background: Myocardial revascularization is a common surgical intervention for those with coronary artery disease (CAD). However, for individuals who undergo this procedure, there is considerable risk for developing post-operative pulmonary complications (PPCs). Results of some studies suggest device-guided breathing training may prevent PPCs in this population. Purpose: To investigate the effects of device-guided (resistive vs. non-resistive) breathing training on key post-operative outcomes; length of stay (LOS), maximal inspiratory pressure (MIP), peak expiratory flow (PEF), and six-minute walk test (6MWT). Methods: Databases including PubMed, Google Scholar, Ovid MEDLINE, Embase, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, EBSCOhost CINAHL Plus with Full Text, and Scopus were searched to identify and retrieve all relevant references. In addition to direct source searching, references in the bibliographies of key articles and review articles also were reviewed to identify relevant studies. The Physiotherapy Evidence Database (PEDro) scale was used to evaluate each study for quality and risk of bias. Results: Twenty-one studies were identified for inclusion. Resistive breathing training resulted in no change in MIP [4 studies; n=154; SMD=0.01 (95% CI: -0.66, 0.69)] and a small decrease in LOS [4 studies; n=154; SMD=0.19 (95% CI: -0.42, 0.80)]. PEF and 6MWT were not analyzed due to insufficient number of studies. There was no effect of non-resistive breathing training on any parameter. Conclusions: Short-term resistive breathing training shows no benefit for MIP, and minimal benefit for LOS. Importantly, resistive breathing training performed pre-operatively is more effective in improving LOS and MIP compared to post-operative training. Further, low levels of resistive breathing training (i.e., <40% MIP) have no effect on either MIP or LOS. Additional research to compare pre-operative, post-operative versus pre- and post-operative interventions strategies is warranted.
  • SRC KINASE PLAYS A SEXUALLY DIMORPHIC ROLE IN THE MECHANISM UNDERLYING INTERMITTENT FASTING ENHANCED OPIOID ANTINOCICEPTION

    Streicher, John; Seekins, Caleb Alan (The University of Arizona., 2023)
    With its variety of positive reported effects, intermittent fasting was previously hypothesized to decrease negative outcomes associated with opioids. Ultimately, intermittent fasting combined with opioid therapy was shown to increase the antinociceptive effect of the opioids while decreasing the negative side effects, including abuse liability (1). In this study we thus attempted to elucidate the mechanism behind this enhancement of opioid antinociception by intermittent fasting. Proteomics was first performed in the spinal cord and significant differences in Src inhibitor 1 (Srcin1) was found between fasted and ad libitum mice, suggesting a role for Src kinase in this pathway. Western blotting was conducted, the results of which confirmed that in spinal cords Src kinase phosphorylation was increased by intermittent fasting. Next, Src inhibitor was administered to opioid treated fasted mice, which showed that enhanced opioid antinociception was abolished in male mice but not females. This sexually dimorphic effect was supported by immunohistochemistry, which showed that only in intermittent fasted opioid stimulated male mice, Src phosphorylation was greatly increased in the dorsal horn. Finally, colocalization was performed, though these results are preliminary, and no significant results have currently been found. Ultimately, these results suggest that decreased Srcin1 levels cause an increase in Src phosphorylation, regardless of sex, following intermittent fasting. Following opioid treatment, the dorsal horn of intermittent fasting male mice has increased Src phosphorylation that mediates enhanced antinociception. This has uncovered a role for Src kinase in intermittent fasting and opioid antinociception, as well as sexual dimorphism seen in both.
  • DRIVERS OF ALTITUDINAL MIGRATION IN UNGULATE SPECIES

    Alston, Jesse; Satterfield, Paige Alyse (The University of Arizona., 2023)
    Migration is extremely important both at the species and ecosystem level, however most research has focused on long-distance migrations. Without an understanding of short-distance migrations, like altitudinal migration, it can be hard to predict how species will be affected by rapid changes in the environment. Migratory ungulates are of special conservation importance as many are keystone species, having significant effects on ecosystem processes. In this study, I provide an overview of the drivers of altitudinal migration in ungulates and discuss its importance in ecology and conservation. Through a review of case studies of various ungulate species, I found four drivers of altitudinal migration: forage quality and quantity, predator avoidance, weather, and pest avoidance. While a pattern of forage quality and quantity emerged as one of the main mechanisms underlying altitudinal migration, most migrations were driven by a combination of the four factors. This knowledge helps better our understanding of altitudinal migration in ungulates, however more research is needed on how climate change, habitat fragmentation, and other environmental factors influence these species. I conclude by discussing future research directions for the study of altitudinal migration in ungulates and how these can be conducted.
  • STUDENT OUTCOMES BASED ON PERCEPTIONS OF TEACHER QUALITY

    Hunter, Martin; Murdoch, Jack (The University of Arizona., 2023)
    In this paper, we examine the effects of student perception of teachers on long term student outcomes. Using data from the National Longitudinal Survey of Youth with nearly 9,000 observations, we construct three multiple linear regression models with dependent variables: income, natural log of income, and highest grade completed regressed against student ratings of their teachers along with several relevant demographic variables. We find that students who rated their teachers highly were more likely to have a higher income later in life. Having a teacher perceived as bad had no statistically significant effect on long term income. Students who rate their teachers highly complete more years of education on average and those who rate their teachers poorly complete less years of education on average. These findings lead us to conclude that the quality of a school’s teachers matters in the long run for a student’s success both academically and financially.
  • TEACHING ASSISTANTS ON THE FRONT LINES: A STUDY OF A COMPUTER SCIENCE DEPARTMENT'S PROGRAM

    Lewis, Russell; Ioane, Kapua (The University of Arizona., 2023)
    The Undergraduate Teaching Assistant (UGTA’s) Program within The University of Arizona’s Computer Science Department has been wildly successful over the past half decade. With more than 1200 undergraduate students, class sizes, especially at the introductory level, can be quite large. UGTAs are a crucial resource to both students and professors in these larger courses. However, the program faces challenges and has the potential to grow - most notably in its need for training the UGTAs when they are first hired and the need for more flexibility within the job. Improvements aimed at addressing these areas have been developed and launched in the past year. These improvements include a two day training program that newly hired UGTA would be required to participate in as well as a new position for experienced UGTAs to demonstrate growth and experience - both of which were launched in the Spring 2023 semester.
  • INVESTIGATING HOW THE UNEXPECTEDNESS OF A DEATH AFFECTS THE SEVERITY OF GRIEF: A SCOPING REVIEW

    O'Connor, Mary-Frances; Higgins, Cassandra Leigh (The University of Arizona., 2023)
    There is a knowledge gap in grief literature regarding unexpectedness (the perception of unpreparedness for the death of a loved one) being predictive of higher grief severity during bereavement. Many studies that researched grief severity during the COVID-19 pandemic included or found the factor of unexpectedness to be significant. The aims of this scoping review are to discover if the findings of the published literature can conclude that unexpectedness is predictive of higher levels of grief, and if it is a significant factor related to greater bereavement distress from the loss of a loved one due to the COVID-19 pandemic. Using the databases PubMed and PsycInfo, sources were collected and screened for their eligibility to be included in this study. The findings of each study were then extracted based on their relevance, organized, then synthesized. The synthesis of findings can conclude that the unexpectedness of a death is predictive of acute grief and a risk factor for prolonged grief, and that it is a significant factor associated with greater bereavement distress during a pandemic. Experiencing what is perceived to be an unexpected death can predict more severe grief experiences.
  • GUT INSTINCTS: NAVIGATING THE MICROBIAL MAZE IN MULTIPLE SCLEROSIS

    Cholanian, Marina; Goldfine, Matthew Alexander (The University of Arizona., 2023)
  • FROM INCARCERATION TO BEYOND: A LITERATURE REVIEW ON MENTAL HEALTH, TREATMENT, AND REENTRY IN THE INCARCERATED POPULATION

    Langley, Carrie; Fisher, Jamie (The University of Arizona., 2023)
    The United States corrections system is one of the largest psychiatric providers in the country, yet many incarcerated people do not receive adequate mental healthcare during their sentences. When ready to re-enter into society, inadequacies in transitional programs continue to challenge former inmates to maintain sobriety and employment. It is important to mention that many people who have served prison sentences have a history of substance abuse related to mental illness. This literature review aims to discuss current practices and the gaps in continued treatment.
  • SIN MIEDO: A COMMUNITY BASED ART EXHIBITION

    DiCindio, Carissa; Campos, Alexis G. (The University of Arizona., 2023)
    SIN MIEDO explores the theme of Chicanx beauty, aesthetics, culture, and imagery. It is a dialogue between Chicanx community artists from Tucson, myself as the curator, and viewers as they explore this theme through their own experiences, identity, culture, belief systems, and memory. This exhibition and the space utilize a community-centered approach which the exhibition is built around. The work created by the artists guides the conversation and dialogue concerning the theme. While the theme has been provided, each artist has their subjectivity and positionality that allows them to create work that is complex and important to be publicly shown. Sin Miedo encapsulates museum theories and practices of community art, institutional critique, decolonizing the white cube space, and participatory art. Sin Miedo also has an immense focus on the beauty and imagery aspects of Chicanx arts, filtered through a feminist lens, that incorporates those same museum practices and theories. This exhibition is designed to broadcast the voices of Chicanx community artists of Tucson and allow the audience to engage and immerse themselves in the gallery space and theme. Every artist that participates has their own unique story to tell as the Chicanx culture is as diverse as the experiences it brings.
  • THE STUDENT ASSISTANT DIRECTOR'S GUIDEBOOK

    Makino, Yuri; Bussey, Caitlin (The University of Arizona., 2023)
    The goal of this Guidebook is to enable a university film student, with little to no previous experience as an Assistant Director, to fulfill the AD's role on any class project. On any film or TV show, the AD is the event manager of the production, responsible for scheduling, organizing and day-to-day supervision and leadership on the set. The AD is the project's prime communicator and coordinator as they strive to provide their Director, cast, and crew with the maximum resources available within the project’s budget and time limitations. While crucial to any production, the craft of the Assistant Director is rarely taught in university film schools. There is no UA FTV course dedicated to teaching all of the skills needed to be an Assistant Director. Basic budgeting and scheduling are covered in the second semester of the producing course series, but this is an elective that not all students in the program will have the opportunity to take. This Guidebook is a tutorial for those without AD experience, and a reference tool for those looking to improve their performance.
  • DEVELOPMENT OF A QUESTIONNAIRE AND SUBSEQUENT INVESTIGATION OF STUDENT PERCEPTIONS OF PRIMARY PROGRESSIVE APHASIA

    Kielar, Aneta; Abraham, Emily Judith (The University of Arizona., 2023)
    Primary Progressive Aphasia (PPA) is a neurodegenerative disorder characterized by language and communication deterioration in the initial stages of the disease (1-3 years). Given that PPA progresses over the course of years, patients with PPA require interdisciplinary teams of practitioners to provide effective care, including physicians and speech-language therapists. These practitioners should be well-educated about and hold respectful attitudes towards PPA so that patients receive optimal care. The goal of this study was to investigate university students' perceptions of PPA as characterized by both baseline knowledge and positivity of attitude. New scales-- the PPA Knowledge Scale (abbreviated PPAk; assessing knowledge of PPA) and the PPA Attitudes Scale (abbreviated PPAa; assessing attitudes towards PPA)-- were developed for this purpose and administered alongside previously validated scales related to aging and dementia. Pre-health and communication science disorder students were surveyed initially because these students will become the next set of practitioners for patients with PPA. The results indicated that while knowledge of PPA among surveyed students is lacking, attitudes towards PPA are relatively positive. Suggestions for future research include continued evaluation of the PPAk and PPAa scales. There is a need for educational initiatives to provide students with more instruction regarding PPA in the health related fields at the undergraduate level.
  • An Analysis and Performance Guide of Chinese Representative Viola Works by Qingwu Guan, Nian Liu, and Bright Sheng

    Gebrian, Molly; Dong, Xiaochen; Kantor, Timothy; Traut, Don (The University of Arizona., 2024)
    This document delves into five Chinese representative viola pieces: The Sound of the Mongolian Grassland (Caoyuan Zhige 草原之歌) by Qingwu Guan , First Suite for Solo Viola by Nian Liu, and Three Chinese Love Songs, Angel Fire Duo, and The Stream Flows by Bright Sheng. These works contain numerous uniquely Chinese musical elements including pitch collections, folk song melodies, viola performance techniques. By incorporating such Chinese elements and folk melodies into their compositions, these composers have bridged cultural gaps between China and Western countries, thereby instilling a deeper appreciation of Chinese musical heritage on a global scale. Their shared contributions to the incorporation of Chinese compositional elements into viola music has helped to foster the development of Chinese viola repertoire.
  • Incompressible Miscible Rayleigh-Taylor Instability Experiments on the University of Arizona Linear Induction Motor Drop Tower Using Planar Laser Induced Fluorescence

    Jacobs, Jeffrey W.; Withers, Clayton James; Craig, Stuart A.; Schluntz, Justine (The University of Arizona., 2023)
    Incompressible miscible Rayleigh-Taylor instability (RTI) experiments are described that utilize the University of Arizona’s vertical Linear Induction Motor (LIM) drop tower. RTI is a buoyancy driven instability occurring at the interface between two fluids of differing densities, represented by the Atwood number, where a destabilizing acceleration causes initial perturbations along the interface to develop into characteristic spike and bubble formations. The incompressible fluid pair used in the research is a miscible combination of isopropyl alcohol solution and calcium nitrate salt solution. Experiments were conducted at Atwood numbers of 0.150 and 0.216. The experiments conducted at an Atwood number of 0.216 are used as a replication of previous research to allow comparisons to the experiments conducted at Atwood values of 0.150. The fluid solutions used in experiments conducted at the Atwood value of 0.150 have been initially mismatched in refractive index as part of an examination of possible techniques for improving imaging issues commonly experienced by miscible experiments. An acrylic tank attached to an experimental aluminum reaction plate is mounted to the LIM drop tower and filled with the two fluids in an initially stratified configuration. The reaction plate, along with the fluid tank and diagnostic equipment, is vertically raised to the top of the LIM drop tower and subsequently accelerated downward at an effective constant acceleration of approximately 11.7 g, developing the fluid instability. Acceleration is accomplished by the interaction between the LIM drop tower’s parallel set of linear induction motors and the aluminum reaction plate that is vertically constrained within the rails of the drop tower. Deceleration is accomplished with a set of permanent magnetic brakes located at the base of the LIM drop tower. Acceleration is recorded using a single axis accelerometer mounted to the experimental test sled. Imaging equipment is rigidly attached to the test sled and provides visualization from a static viewpoint of the experimental tank. Both unforced and forced experiments are conducted, where an electrically driven actuator is used to provide vertical parametric forcing of the experimental test sled. Experiments are imaged using planar laser induced fluorescence (PLIF) to visualize the instability interface. A swept 445nm laser light beam that illuminates fluorescein dye mixed into the calcium nitrate solution allows planar visualization of the instability interface and experimental images are captured using a monochrome high-speed shock-rated digital camera that documents the experimental process. Resulting images expose a single plane of the developing RTI. Postprocessing follows in which a pixel level concentration profile is obtained. The concentration profile is used to provide measurements of the mixing process. From the concentration profile, a mixing region width is extracted and subsequent measurements of the instability growth constant, α, are obtained. Two methods for calculating α are used. Calculated α values for experiments at an Atwood number of 0.150 are in the range of 0.076–0.118 and the α values for Atwood numbers of 0.216 are in the range of 0.021-0.063, depending on measurement method. Comparisons of the measured α values to α values from previous experiments are made, noting that the reported α values are higher than what might be typically expected for similar experiments. A spectral analysis to examine the prevalent wavelengths during the experiment is completed and finds that forced experiments featured earlier development of dominant wavelengths when compared to unforced experiments. An analysis of the effects of refractive index variation on image sharpness using gradient-based focus measures is performed, but considered inconclusive.
  • Experiments on the Three-Layer Richtmyer Meshkov Instability

    Jacobs, Jeffrey; Schalles, Mark David; Craig, Alex; Chan, Cholik (The University of Arizona., 2024)
    The Richtmyer-Meshkov fluid instability (RMI) can be considered a particular case of the broader Rayleigh-Taylor instability (RTI), in the situation that the fluid interface is impulsively accelerated, as is the case when such an instability is impacted by a shock wave. The study of RMI has significant applications to the research of the Internal Confinement Fusion (ICF) method of nuclear fusion, which involves the superheating of fuel contained within a capsule consisting of multiple, closely spaced layers of material each affected by the formation of such instabilities under such conditions. One important quantity studied in RMI applications is that of the growth in amplitude of the instability structures as they develop from an initial sinusoidal perturbation at the interface, and this property is the main focus of the experiments conducted for this study. The effect of placing a secondary, unperturbed interface just above the well-studied single-interface configuration is studied for its effect on the amplitude growth in the nonlinear regime of RMI. The effects of the presence of this secondary interface are considered with two different gas combinations all of varying density, with a third gas added for a second interface and studied alongside the results of the one-interface case. The gases are vertically stratified in a shock tube with the lightest gas entering at the top, the heaviest gas at the bottom, and the middle layer gas emitted through porous metal plates near where the interface is formed. Experiments are visualized by illuminating one gas seeded with particles with a light sheet from a pulsed laser, with recordings captured by a single high-speed video camera. Amplitudes are measured by defining the interface position at each frame by its maximum brightness gradient and finding its maximum vertical span. The data suggests that the presence of the second, unperturbed interface causes a decrease in amplitude growth during the nonlinear regime of the instability development. Continued research is proposed to explore the accuracy of and reasons for the observations made.
  • Exploring Indigeneity in English Language Teaching Through Turi Aisa Ya With Indigenous Miskitu Teachers of English

    Nicholas, Sheilah E.; Mejia Mayorga, Jaime Fabricio; Tardy, Christine M.; Combs, Mary Carol (The University of Arizona., 2024)
    This dissertation explored the aspect of Indigeneity as a significant consideration in English Language Teaching (ELT); and thus makes a critical contribution to the literature in ELT/TESOL and applied linguistics. This body of knowledge benefits from privileging Indigenous ways and Indigenous knowledge in research practices, making explicit understandings on language use and language teaching and learning from Indigenous knowledge systems, Indigenous and postcolonial sites, and incorporating ethical approaches to research that empower all parties involved (Norton and Tohey, 2011; Pennycook & Makoni, 2020; Sterling & De Costa, 2018). As such, this dissertation was informed by Indigenous and decolonizing research methodologies that contribute to decoloniality and the advancement of Indigenous knowledge in academia. The exploration of the aspect of Indigeneity in ELT was conducted by investigating the stories and experiences of two Indigenous Miskitu teachers of English from Honduras. Additionally, the exploration includes a prologue in which the principal researcher narrates the awareness of his Indigeneity as Indigenous Chorotega in storying his life history. Consequently, I define Indigeneity as a quality of being Indigenous encompassing: as embracing Indigenous worldviews, paradigms, and ways of being, doing, knowing, and thinking (Garroutte, 2006; Huaman, 2022; Peltier, 2021); as the self-identification as Indigenous; as the awareness and interest on one’s spirituality and well-being; as the use in, interest on, and passion for one’s Indigenous language and culture (Huaman, 2022; Peltier, 2021); as the connection to Indigenous people by blood, kinship, or ancestry (Garroutte, 2006; Simpson, 2011) as well as to one’s Indigenous land, place, and community (Absolon, 2011; Sarivaara et al., 2013). The study investigated the stories and experiences of two Indigenous Miskitu teachers of English as former students of an ELT program in Honduras and current teachers of English in the public education system of Honduras. It sheds light in understanding how the Indigeneity of these Indigenous Miskitu teachers of English intersected with their preparation and professionalization as English language teachers and how their Indigeneity informs and impacts their teaching praxis. The study used turi aisa ya, an Indigenous Miskitu methodology, for data collection (Smith, 2012). Turi aisa ya is a space for sharing and the exchange of information and experiences; it requires sitting down and listening with humbleness and intention—listening to hear. Turi aisa ya is also a social activity in which participants engage in laughing, thinking together, crying, worrying, and coming up with solutions. It is imagining, experiencing vicariously, and feeling. In a similar manner to sharing circles (Lavallée, 2009), turi aisa ya is an approach “used to capture people’s experiences [and is] comparable to focus groups in qualitative research” (p. 28). In addition to turi aisa ya, the participants engaged in storywork as we were storying our intersecting lived experiences as a way of making and gaining insights from our life stories (Archibald, 2008). Engaging in turi aisa ya and storywork created the space for dialoguing about their beliefs on education merging traditional Miskitu worldviews with English language learning, English language teaching, and their lived experiences teaching in the Honduran public education system as Indigenous Miskitu teachers of English. Findings shows that the Indigeneity of the Indigenous Miskitu teachers of English, who were co-researchers on this study, was important and influential in their becoming teachers of English. First, their Indigeneity is understood as anchored in intergenerational relations as well as family and community relations, thus informed their desires to become teachers of English. Secondly, their awareness and consciousness towards the English language informed their becoming as teachers of English. Such awareness and consciousness served as a reminder on why pursuing a bachelor’s degree in ELT was relevant to them. Third, their personal traits of hard-work, resolution, commitment, and determination, aspects of their Indigeneity, intersected with their becoming as teachers of English. Said personal traits ensured that both Zoila and Wesley negotiated and navigated newer spaces and situations as they moved to new locations to pursue higher education and invested themselves in mastering English as their third language --a language that for them served community-oriented, professional, and academic purposes. Moreover, the dialogues held during the turi aisa ya sessions helped identify the ways in which their Indigeneity manifests in their teaching praxis. Their Indigeneity is manifested in their teaching praxis as reciprocity in the classroom, through the centering of well-being through a pedagogy of kindness and care, via culturally responsive teaching, and in the use of storytelling as a pedagogical tool. While these are some of the ways in which their Indigeneity is manifested in their teaching praxis, they are not the only ones considering that, as Zoila stated, “[their] Indigeneity is present in everything [they] do” (Zoila, Turi aisa ya session # 4 with Zoila. Jan, 13, 2023). Furthermore, the curricular innovations to the ELT teacher education program in Honduras, that emerge from their stories and experiences, include: (a) a class to learn about Indigenous Miskitu ways, (b) English language [pre-service] teachers learning about the linguistic diversity of Honduras, (c) representation in faculty and instructors, (d) additional preparation for students in the ELT program to teach in the public education system of Honduras, (e) formal academic and educational spaces to learn about the current state of Indigenous communities in Honduras, and (f) training students in the ELT program under the paradigm of Teaching English as a Global Language from an Indigenous relational paradigm. Key conclusions and implications for ELT teacher education in Honduras and beyond are: a) English should be taught as an additional language, b) multilingualism is as an aspect of our identities as we might be trilingual individuals (users of three languages or users of two languages and heritage speakers of an Indigenous language), and c) the ways teachers of English are educated should be innovated by a new paradigm that is encompassing of multilingual education and the fact that English is a global language. Noteworthy to identify are the limitations that impacted this study. These include a lack of Indigenous knowledge in the fields of ELT/TESOL and applied linguistics, the realities exacerbated by COVID-19 even post-pandemic, and the small number of Indigenous Miskitu teachers of English. The possibilities for future research suggest that this study could be replicated with the collaboration of more Indigenous Miskitu teachers of English as well as other teachers of English who belong to other ‘ethnic’ communities such as the Garifuna and Islanders. Also, further research could instigate other critical dialogues to gain insights into the multilingual realities of all these individuals. Furthermore, this study could be replicated to learn how other Indigenous teachers of English throughout the world teach this language as informed by their Indigeneity. Lastly, further research that builds from this dissertation could investigate how the teaching of languages such as English could look like if informed by an Indigenous relational paradigm. Keywords: Indigeneity, Indigenous Knowledge, Miskitu, Honduras, English Language Teaching, TESOL, Applied Linguistics, Global Englishes, teacher education.
  • Platelet Activation: Association with NADPH Oxidase Expression and Reactive Oxygen Species Generation in High-Shear Environments

    Slepian, Marvin J; DiCaro, Michael Vincent; Singh, Aditi; Lybarger, Lonnie (The University of Arizona., 2023)
    Thromboembolic complications remain a major cause of morbidity and mortality among patients with mechanical circulatory support devices for heart failure. Mechanical circulatory support devices, including ventricular assist devices (VADs), artificial hearts, and other cardiovascular therapeutic devices, produce significant intravascular shear which leads to turbulent blood flow and enhanced thrombotic activity. Reactive oxygen species (ROS) have been implicated as inflammatory mediators of platelet activation and thrombosis. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase plays an important role in ROS production. To further evaluate the role of NADPH oxidase 4 (NOX4) and ROS in shear conditions seen in VADs, this study examined the effect of hemodynamic shear stress on NOX4 expression and subsequent production of ROS in human platelets with fluorescent immunostaining to show NOX4 localization. Additionally, this study explored the effect of hydrogen peroxide (H2O2) on shear-mediated platelet activation. Correspondingly, ROS levels were positively correlated with an increase in NOX4 expression; excess ROS most likely resulted in exacerbation of shear-mediated platelet activation. Also, H2O2 resulted in an additive effect on shear-mediated platelet activation. Our results suggest a possible link between shear-mediated activation of platelets and NOX4-induced ROS production. Shear-mediated platelet activation is a dynamic process involving multiple biologic and mechanical elements. These findings contribute to a better understanding of thrombotic complications in patients with flow-altering implantable cardiovascular devices.
  • Clinician Education: Optimizing Music Choices for Ketamine-Assisted Psychotherapy

    Velo, Jamie R.; Chenette, Christie Iliana; Young, Janay R.; Edmund, Sara J.; Reed, James R. (The University of Arizona., 2024)
    Purpose:The purpose of this quality improvement project was to increase clinician knowledge regarding evidence-based music selections for ketamine-assisted psychotherapy at a local clinic. Background: Ketamine is used to treat a variety of mental health issues. Set and setting have been identified as important variables that support the tolerability and efficacy of ketamine. Music is one key variable that clinicians can utilize to optimize the therapeutic experience; however, not every provider is knowledgeable regarding how to best do this. Methods: This quality improvement project was delivered as an educational presentation for clinicians at Tucson Counseling Associates. The presentation was created based on published literature and evidence provided as a multi-media PowerPoint lecture including examples of appropriate music choices and a case study. Data was collected through a pre- and post-survey questionnaire, which was used to assess baseline knowledge and knowledge gained after the lecture. The surveys utilized a five-item Likert scale and short-answer format questions. A number was assigned to each Likert scale rating (strongly disagree = 1, disagree = 2, neutral = 3, agree = 4, strongly agree = 5) and thenumber of responses for each item on the scale was factored in. Free text responses were reviewed for major themes. 12 Results:Participant perception of current clinic practices indicated that clinicians agreed that music was intentionally selected at Tucson Counseling Associates with an average Likert-scale score of 4.43. Clinicians agreed that they understood why certain music is used for patients. The post-survey results indicated a statistically significant improvement in knowledge gain compared to the pre-survey results. Participants strongly agreed that they learned valuable information during the presentation and that they intend to use the information in their future practice. The free-response questions indicated six unique ways in which participants intend to use this new information in their clinical practice and provided insights on how to improve the intervention moving forward. Conclusions: Results suggest the efficacy of an interactive multi-media PowerPoint lecture with an incorporated case study in increasing clinician understanding and confidence in choosing appropriate music choices for KAP sessions to help optimize the patient experience.
  • The Cahuilla Research Agenda Model: Using Indigenous Methods and Cahuilla Traditional Knowledge in Research

    Trosper, Ronald L.; Lewis, Larea Mae; Reader, Tristan; Ferguson, T.J.; Tatum, Melissa L. (The University of Arizona., 2023)
    Years of settler colonialism, annihilation, and assimilation caused our tribal communities to lose precious traditional knowledge in cultural traditions and our relationships to land. The relationships between people and land are significant because we create physical and cultural identities based on our life experiences while living on the landscape. We create realities that explain our presence and we make meaning of our surrounding environments. As a culture, we pass the knowledge down to our future generations, so they know where they come from and how to give respect and thanks to our Ancestors and our Creators. In return, our Ancestors give us the gifts of life. To disturb our relationship with the land is to disturb our culture and our identity. In efforts to preserve culture, researchers throughout time have documented traditional knowledge in Cahuilla language, history, traditions, and stories. Oral stories, language and traditions have also been recorded by Cahuilla Elders in books, phonographic records, and tapes. Although Cahuilla cultural studies continues with the use of these sources, it is not common practice for researchers to engage with Cahuilla communities to help with the research. Their research also does not fully accomplish the goal of directly reconnecting us to our culture or our relationships to our traditional land. In this research, I engage with my community to change the narrative and bring forth their voice in helping us reach those goals. I apply Indigenous methodologies which are methods of research that are guided by traditional knowledge systems and worldviews. Applying these methods changes the course in how knowledge is shared between the researcher and the community and how we reach researcher and community goals. Furthermore, using these methods requires us to create a research framework that includes tribal ethics, tribal sovereignty, and worldview. In this research, we explore Indigenous research methods and engage with the Agua Caliente Band of Cahuilla Indian tribe to create a research agenda model that can be used in further research studies on their culture. As an example, we explore how the Cahuilla Research Agenda model is used by applying its research methods to an ongoing research project that studies the traditional use of plants, the Cahuilla Plant Database Project. Our goal is to reconnect the Agua Caliente Band of Cahuilla Indians to their traditional homelands and revitalize cultural ways of life by doing research by, with, and for the community.
  • Sizing a Space Telescope for Exoplanet Studies: A Systems Engineering Case Study

    Douglas, Ewan; Carter, Alex; Ingraham, Patrick; Chalifoux, Bandon (The University of Arizona., 2024)
    Systems Engineering is an involved and non-standardized process that can vary dramatically even within different parts of the same project. Here I present a case study for applying systems engineering techniques to an optomechanical problem for a space based telescope. This telescope is being used to study exoplanetary systems and is very similar in concept and in design specifications to the Nancy Grace Roman Space Telescope. It includes active wavefront control and a coronagraph to improve the exoplanet detection capabilities. Here I discuss the design decisions that went into determining the appropriate size for the primary mirror of the telescope. The end goal is to have a telescope primary that is sufficiently large to obtain signal to noise ratios required to detect exoplanets. The process I used here involved preliminary orbital design work for the telescope, understanding the behavior of the rest of the optics within the telescope system, the output and geometry of the target planetary systems, and balancing the desired SNR with reasonable design constraints on the size of the primary.
  • Moving Beyond the Decolonization Framework: Indigenous Research, Collaboration, and Decision-Making in Mi’kma’ki

    Trosper, Ronald L.; Starks, Rachel Rose; Gonzales, Patrisia; Begay, Jr, Manley A.; Tatum, Melissa (The University of Arizona., 2024)
    This dissertation is divided into three parts. Part I addresses the researchquestion, literature review, and methodologies. Part II is a treatment of original research that took place at Membertou Mi’kmaq Band between 2010 and 2013. The community centered research model is described in detail, which is followed by new analysis of data that was collected during that community-centered research. Part III discusses the context of Mi’kmaq Nation action over the last several decades. This action is influenced by the experience of Donald Marshall, Jr. in two major legal cases: 1) Marshall’s wrongful conviction and incarceration for murder, and then exoneration; and 2) Marshall’s arrest for violating provincial fishing laws, leading to a landmark decision on Mi’kmaw land, hunting and fishing, and commerce rights. Both these cases, along with evolving standards for Aboriginal rights, consultation, and accommodation, and changing institutional arrangements at Mi’kmaq led to the collaborative governance regime, the Made in Nova Scotia Process.

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