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- We're celebrating the 5-year anniversary of the UA Open Access Policy. The UA Faculty Publications collection has grown to more than 9,400 articles published by UA researchers. We thank all our UA affiliates for contributing their articles under the policy!
- Please join us in welcoming the Arizona Journal of International and Comparative Law to our repository community. Articles from Volume 38, Issue 2 are now publicly available. The full backfile will be added over the next several weeks.
- Rangelands, Volume 39 (2017) is now publicly available in the repository.
- Do you have research data and code to share? Visit ReDATA, The University of Arizona Research Data Repository to learn how to make your data and code available in compliance with funder mandates
- Rangeland Ecology & Management, Volumes 67-68 (2014-2015) are now publicly available in the repository.
- Tree-Ring Research, Volume 71 (2015) is now publicly available in the repository.
- Meteoritics & Planetary Science, Volumes 37-44 (2002-2009) are now publicly available in the repository.
- Radiocarbon, Volumes 1-54 (1959-2012) are now publicly available in the repository.
- Theses from Spring/Summer 2020 Honors College graduates are now publicly available in the repository.
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From a crisis to an opportunity: Eight insights for doing science in the COVID‐19 era and beyondThe COVID-19 crisis has forced researchers in Ecology to change the way we work almost overnight. Nonetheless, the pandemic has provided us with several novel components for a new way of conducting science. In this perspective piece, we summarize eight central insights that are helping us, as early career researchers, navigate the uncertainties, fears, and challenges of advancing science during the COVID-19 pandemic. We highlight how innovative, collaborative, and often Open Science-driven developments that have arisen from this crisis can form a blueprint for a community reinvention in academia. Our insights include personal approaches to managing our new reality, maintaining capacity to focus and resilience in our projects, and a variety of tools that facilitate remote collaboration. We also highlight how, at a community level, we can take advantage of online communication platforms for gaining accessibility to conferences and meetings, and for maintaining research networks and community engagement while promoting a more diverse and inclusive community. Overall, we are confident that these practices can support a more inclusive and kinder scientific culture for the longer term.
Design and development of innovative microparticulate/nanoparticulate inhalable dry powders of a novel synthetic trifluorinated chalcone derivative and Nrf2 agonist.Chalcone derivatives are shown to possess excellent anti-inflammatory and anti-oxidant properties which are of great interest in treating respiratory diseases such as acute lung injury (ALI), acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease (COPD), and pulmonary fibrosis (PF). This study successfully designed and developed dry powder inhaler (DPI) formulations of TMC (2-trifluoromethyl-2 ' -methoxychalone), a new synthetic trifluorinated chalcone and Nrf2 agonist, for targeted pulmonary inhalation aerosol drug delivery. An advanced co-spray drying particle engineering technique was used to design and produce microparticulate/nanoparticulate formulations of TMC with a suitable excipient (mannitol) as inhalable particles with tailored particle properties for inhalation. Raw TMC and co-spray dried TMC formulations were comprehensively characterized for the first time using scanning electron microscopy (SEM) with energy dispersive X-ray (EDX) spectroscopy, thermal analysis, X-ray powder diffraction (XRPD), and molecular fingerprinting as dry powders by ATR-FTIR spectroscopy and Raman spectroscopy. Further, biocompatibility and suitability of formulations were tested with in vitro cellular transepithelial electrical resistance (TEER) in air-interface culture (AIC) using a human pulmonary airway cell line. The ability of these TMC formulations to perform as aerosolized dry powders was systematically evaluated by design of experiments (DOEs) using three different FDA-approved human inhaler devices followed by interaction parameter analyses. Multiple spray drying pump rates (25%, 75%, and 100%) successfully produced co-spray dried TMC:mannitol powders. Raw TMC exhibited a first-order phase transition temperature at 58.15 +/- 0.38 degrees C. Furthermore, the results demonstrate that these innovative TMC dry powder particles are suitable for targeted delivery to the airways by inhalation.